Examining the Effector Mechanisms of the Feishu Acupoint (BL13) in the Treatment of Pneumonia Based on Systematic Acupuncture and Moxibustion Research

Table 4

Top 10 Reactome enrichment results for the Feishu point efficacy system.

Reactome ID	Reactome description	FDR	Matched element
HSA-1280215	Cytokine signaling in the immune system	7.18E − 12	ADAM17, CASP3, FASLG, FCER2, IFNGR1, IL12RB1, IL1B, IL2RB, IL4R, IL5RA, IL6R, MYD88, SQSTM1, STAT6, and TGFB1
HSA-449147	Signaling by interleukins	1.31E − 11	CASP3, FASLG, FCER2, IL12RB1, IL1B, IL2RB, IL4R, IL5RA, IL6R, MYD88, SQSTM1, STAT6, and TGFB1
HSA-162582	Signal transduction	1.23E − 08	ADAM17, BAD, BAX, CASP3, CCL1, CCR8, CDH1, CTNNBIP1, FAS, FASLG, FCER2, IL2RB, IL5RA, IL6R, MC2R, MYD88, SQSTM1, STAT6, TGFB1, and WNT3A
HSA-6785807	Interleukin-4 and Interleukin-13 signaling	3.34E − 08	FASLG, FCER2, IL1B, IL4R, IL6R, STAT6, and TGFB1
HSA-73887	Death receptor signaling	1.62E − 07	ADAM17, BAD, CASP3, FAS, FASLG, MYD88, and SQSTM1
HSA-168256	Immune system	4.40E − 07	ADAM17, CASP3, CDH1, FASLG, FCER2, IFNGR1, IL12RB1, IL1B, IL2RB, IL4R, IL5RA, IL6R, MYD88, SQSTM1, STAT6, and TGFB1
HSA-109581	Apoptosis	9.96E − 06	BAD, BAX, CASP3, CDH1, FAS, and FASLG
HSA-5357801	Programmed cell death	9.96E − 06	BAD, BAX, CASP3, CDH1, FAS, and FASLG
HSA-193704	p75 NTR receptor-mediated signaling	1.68E − 05	ADAM17, BAD, CASP3, MYD88, and SQSTM1
HSA-5357769	Caspase activation via the extrinsic apoptotic signaling pathway	0.00032	CASP3, FAS, and FASLG