The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

Figure 6

Representative photomicrographs showing the effect of the aqueous extract of Garcinia lucida (AEGL) on renal and cardiac histology in adenine-treated rats. The normal structure of the rat kidney is observed in the control group. Kidney from the adenine-treated group presented a general disorganization of the architecture, glomerular necrosis (blue arrow), and diffuse tubular dilatation (yellow arrow). The kidney from adenine + captopril-treated rat showed tiny glomerular degeneration and moderate tubular dilatation. In animals that received adenine + AEGL (150 mg/kg) or + AEGL (300 mg/kg), inflammatory cell infiltration (black arrow) and slight tubular dilatation were observed. Heart photomicrographs showed normal structure in the control group. Important inflammatory cell infiltration accompanied with increased intercellular spaces (green arrows) in adenine-treated animals. Scanty increase in intercellular space was observed in the adenine + captopril group. Extract-treated groups showed only increased intercellular spaces that was substantially reduced with AEGL at 300 mg/kg. Sections were stained with H&E. The kidney was observed at 400x, while the heart was pictured at 100x.