The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

Table 2

Effect of aqueous extract of Garcinia lucida (AEGL) treatments on bodyweight gain and on relative kidney, heart, and left ventricle weight in rats with adenine-induced chronic kidney disease.

Experimental groups	Body weight gain (%)	Kidney weight (g/cm tibia length)	Heart weight (g/cm tibia length)	Left ventricle weight (g/cm tibia length)
Control	11.03 ± 0.80	0 .37 ± 0.01	0.18 ± 0.00	0.14 ± 0.00
Adenine	−3.37 ± 4.07^∗∗	0.87 ± 0,09	0.22 ± 0.01	0.17 ± 0.01
Adenine + captopril (20 mg/kg)	−8.80 ± 2.43	0.65 ± 0,06^∗∗∗	0.18 ± 0.00	0.13 ± 000
Adenine + AEGL (150 mg/kg)	−13.34 ± 3.39	0.45 ± 0.01	0.19 ± 0.01	0.14 ± 0.00
Adenine + AEGL (300 mg/kg)	−2.56 ± 1.19	0.67 ± 0.07	0.20 ± 0.01	0.15 ± 0.00

All values are expressed as mean ± SEM from 6 rats. , , and compared to control and , , and compared to adenine. Data were analyzed with one-way ANOVA, followed by Tukey’s multiple comparison test.