The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats
Table 3
Effect of the aqueous extract of Garcinia lucida (AEGL) or captopril on renal and cardiac-reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD).
Parameters
Organs
Control
Adenine (50 mg/kg/days, i.p)
Distilled water
Captopril
AEGL, 150 mg/kg
AEGL, 300 mg/kg
GSH (μmol/mg of tissue)
Kidney
2.40 ± 0.30
0.44 ± 0.14
0.74 ± 0.23
0.96 ± 0.26
0.49 ± 0.16
Heart
1.38 ± 0.11
1.05 ± 0.16
0.79 ± 0.22
0.67 ± 0.24∗
1.18 ± 0.26
CAT (UI/mg of protein)
Kidney
223.20 ± 13.22
66.65 ± 19.59
124.00 ± 13.99
170.40 ± 8.57
133.50 ± 16.10
Heart
160.30 ± 21.61
108.00 ± 11.60
243.50 ± 31.01
328.10 ± 74.96
114.10 ± 12.93
SOD (U/g of protein)
Kidney
8.37 ± 1.94
2.39 ± 0.45
5.34 ± 1.56
5.06 ± 1.25
6.03 ± 1.58
Heart
7.76 ± 1.18
3.95 ± 0.70
2.36 ± 0.26
2.32 ± 0.54
2.79 ± 0.91
All values are expressed as mean ± SEM from 6 rats. , , and compared to control and , , and compared to adenine. Data were analyzed with one-way ANOVA, followed by Tukey’s multiple comparison test.
