Alkaloid Extract of Moringa oleifera Lam. Exerts Antitumor Activity in Human Non-Small-Cell Lung Cancer via Modulation of the JAK2/STAT3 Signaling Pathway

Figure 1

MOAE inhibits the proliferation of A549 cells. (a) The relative viability of A549, A375, HCT116, Hep-G2, and MDA-MB-231 cells following MOAE (0–400 μg/mL) treatment for 48 h. and vs. 0 μg/mL. The relative cell viability of A549 (b), NCI-H1975 (c), NCI-H1781 (d), NCI-H441 (e), and GES-1 (f) cells following MOAE (0–800 μg/mL) treatment for 24 h or 48 h. , , and vs. 0 μg/mL at 24 h; ^#p < 0.05 and ^###p < 0.001 vs. 0 μg/mL at 48 h. (g) The relative number of colonies of A549 cells after MOAE treatment (0, 100, or 200 μg/mL) for 48 h. vs. 0 μg/mL. (h) The morphological changes in A549 cells after treatment with different concentrations of MOAE (0, 100, or 200 μg/mL) for 48 h. The results are expressed as the mean ± SEM of three independent experiments.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)