MiR-203 Targets to the 3′-UTR of SLUG to Suppress Cerebral Infarction-Induced Endothelial Cell Growth and Motility

Figure 1

MiR-203 expression is downregulated in serum samples derived from patients with ischemic infarction, brain tissues from MCAO mice, and hypoxia-induced HUVECs, and its expression is negatively correlated with SLUG. (a) The expression of circulating miR-203 in patients with ischemic infarction compared with healthy control. (b) The expression of miR-203 in brain tissues of MCAO mice in 1 h and 2 h experimental groups compared with normal control. (c) SLUG expression in brain tissues of MCAO mice treated with 1h- and 2h-occlusion compared with normal control. (d) Correlation analysis of miR-203 and SLUG expression in brain tissues of MCAO mice. (e, f) Western blot to determine the protein level of SLUG in brain tissues of two groups of MCAO mice compared with normal control (n = 3). The relative protein level of SLUG was shown in (f). (g) miR-203 expression in hypoxia-induced HUVECs, compared with normal cells. (h) SLUG expression in hypoxia-induced HUVECs compared with normal cells. (i) Western blot analysis to evaluate the protein level of SLUG in hypoxia-induced HUVECs compared with normal cells. , versus control.

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