Exploring the Mechanism of Panax notoginseng Saponins against Alzheimer’s Disease by Network Pharmacology and Experimental Validation

Table 2

Result of KEGG pathway enrichment analysis.

Term ID	Pathway name	Count	FDR
hsa04080	Neuroactive ligand-receptor interaction	48	6.66E − 56
hsa05200	Pathways in cancer	45	1.02E − 39
hsa04151	PI3K-Akt signaling pathway	30	2.71E − 25
hsa05167	Kaposi’s sarcoma-associated herpesvirus infection	25	2.71E − 25
hsa01522	Endocrine resistance	21	3.65E − 25
hsa05212	Pancreatic cancer	19	7.79E − 24
hsa05205	Proteoglycans in cancer	24	1.34E − 23
hsa01521	EGFR tyrosine kinase inhibitor resistance	19	1.39E − 23
hsa04933	AGE-RAGE signaling pathway in diabetic complications	18	1.86E − 20
hsa04012	ErbB signaling pathway	16	1.63E − 18
hsa05206	MicroRNAs in cancer	18	1.27E − 17
hsa05215	Prostate cancer	16	1.29E − 17
hsa04068	FoxO signaling pathway	17	3.22E − 17
hsa05210	Colorectal cancer	15	5.56E − 17
hsa04917	Prolactin signaling pathway	14	1.27E − 16
hsa05203	Viral carcinogenesis	18	2.49E − 16
hsa04066	HIF-1 signaling pathway	14	7.61E − 15
hsa04024	cAMP signaling pathway	17	1.00E − 14
hsa05224	Breast cancer	15	5.98E − 14
hsa05214	Glioma	12	8.70E − 14
hsa04914	Progesterone-mediated oocyte maturation	13	1.03E − 13
hsa05165	Human papillomavirus infection	19	1.03E − 13
hsa05218	Melanoma	12	1.44E − 13
hsa05231	Choline metabolism in cancer	13	1.57E − 13
hsa04659	Th17 cell differentiation	13	2.42E − 13
hsa05220	Chronic myeloid leukemia	12	2.42E − 13
hsa05418	Fluid shear stress and atherosclerosis	14	2.56E − 13
hsa05226	Gastric cancer	14	7.94E − 13
hsa04014	Ras signaling pathway	16	1.06E − 12
hsa05221	Acute myeloid leukemia	11	1.34E − 12