Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats

Figure 1

Schematic diagram of the experimental protocols (a) and assessments on neuroprotective and pyroptosis-inhibiting effects of TXL against cerebral I/R injuries (b–f). (b) Neurological deficits of successful MCAO/R rats with failure to extend right forepaw (white arrow) and circling to the right. (c) Neurological deficit scores of each group, n = 10. (d) Detection of LDH content, n = 4. (e) Representative pictures of PI immunofluorescent staining. The red dots represent the amount of nuclear PI uptake; scale bars, 50 μm. (f) Representative pictures of GSDMD-FL (yellow arrows) and GSDMD-N (red arrows) immunohistochemistry staining; scale bars, 50/20 μm. Data are presented as mean ± SEM.  < 0.01 versus the sham group. ^▲ < 0.05 and ^▲▲ < 0.01 versus the I/R group.