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| Study | Animals | Age, mo | Sample size | Experimental group | Control group | Duration, wk |
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| Pang et al 2010 | C57/BL6J mice | 1 | 10/10/10/10/10 | A : OVX + naringin (200 mg/kg daily); B : OVX + naringin (400 mg/kg daily) | A: sham vehicle (2% ethanol); B : OVX + vehicle; C : OVX + 17b-estradiol (E2, 2 ug/g daily) | 6 |
| Shangguan et al. 2017 | SD rats (body weight, 220 ± 8 g) | 6 | 12/12/12/12 | A : OVX + naringin (200 mg/kg daily); B : OVX + naringin (100 mg/kg daily) | A: sham group (physiological saline solution, 6 ml/kg daily); B : OVX group (physiological saline solution, 6 ml/kg daily) | 12 |
| Li et al. 2014 | SD rats (body weight, 230 ± 10 g) | 6 | 10/10/10/10/10/10 | A : OVX + naringin (40 mg/kg daily); B : OVX + naringin (100 mg/kg daily); C : OVX + naringin (200 mg/kg daily) | A: sham group (H2O); B : OVX group (H2O); C : OVX + E2 (22.5 ug/kg daily) | 12 |
| Song et al. 2016 | SD rats (body weight, 240 ± 12 g) | 3 | 18/18/18/18 | A : OVX + naringin (40 mg/kg daily); B : OVX + naringin (100 mg/kg daily); C : OVX + naringin (300 mg/kg daily) | B : OVX group (normal saline) | 8 |
| Wang et al. 2015 | Unclear | 1 | 5/5/5/5 | A : OVX naringin (5 nM); B : OVX naringin with PTH | A: sham vehicle; B : OVX vehicle (PBS) | 6 |
| Sun et al. 2015 | SD rats (body weight, 230 ± 10 g) | 3 | 15/15/15/15/15 | A : OVX naringin (300 mg/kg daily); B : OVX naringin plus treadmill exercise (300 mg/kg daily + EX) | A: sham group (H2O); B : OVX vehicle; C : OVX exercise | 12 |
| Li et al. 2013 | SD rats (body weight, 220g) | 3 | 6/6/6/6 | A : OVX + naringin (60 mg/kg daily); B : OVX + naringin (300 mg/kg daily); C : OVX + naringin (1500 mg/kg daily) | A : OVX vehicle (PBS) | 8 |
| Li et al. 2012 | SD rats (body weight, 280g) | 4 | 12/12/12/12/12 | A : OVX + naringin (4 mg/kg daily); B : OVX + naringin (2 mg/kg daily) | A: sham group (H2O); B : OVX vehicle (H2O); C : OVX + E2 | 13 |
| Wang et al. 2016 | SD rats (body weight, 230 ± 25 g) | 6 | 10/10/10/10/10 | A : OVX + naringin (1 mg/kg daily); B : OVX + naringin (10 mg/kg daily); C : OVX + naringin (100 mg/kg daily) | A: sham group; B : OVX + N | 4 |
| Zhao et al. 2016 | SD rats (body weight, 230 ± 20 g) | Unclear | 15/15 | A : OVX + naringin (300 mg/kg daily) | A : OVX vehicle (normal saline) | 2 |
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