Research Article
The Effects of Freshwater Clam (Corbicula fluminea) Extract on Activated Hepatic Stellate Cells
Figure 7
CE ameliorates hepatic fibrosis in rats with CCl4-induced liver damage. Wistar rats were implanted with intragastric catheters and were then infused with 0.5 ml corn oil (a, b) or 0.5 ml 20% (v/v) CCl4/corn oil (c, d) into their stomachs twice a week for nine weeks. Next, the CCl4-infused rats were infused with 2 ml water (e, f) or 2 ml CE solution (containing 0.05 g CE) (g, h) every day for four weeks. Finally, the livers were removed for a histopathological analysis after the rats were sacrificed. The liver sections were stained with H&E (a, c, e) or Masson's trichrome stain (b, d, f). Original magnification = 100 ×.
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