Effects of Qinghuang Powder on Acute Myeloid Leukemia Based on Network Pharmacology, Molecular Docking, and In Vitro Experiments

Figure 8

Experimental verification against AML activity of isovitexin in vitro. (a) Isovitexin inhibits the growth of KG1-a cells and HL-60 cells. (b) In KG1-a cell, isovitexin regulated the PI3K-AKT signaling pathway and reduced the expression of Bcl-2. (c) In HL-60 cell, isovitexin regulated the PI3K-Akt signaling pathway and reduced the expression of Bcl-2 in a dose-dependent manner. 1: control group; 2 : 0.39 μmol/L; 3 : 1.56 μmol/L; 4 : 6.25 μmol/L; 5 : 25 μmol/L. GAPDH was used as an internal loading control.

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