Effects of Qinghuang Powder on Acute Myeloid Leukemia Based on Network Pharmacology, Molecular Docking, and In Vitro Experiments

Table 2

Topological analysis of QHP-AML target network.

Protein name	Gene name	ASPL	BC	CC1	CC2	Degree
Cellular tumor antigen p53	TP53	1.114	0.075	0.898	0.463	78
RAC-alpha serine/threonine-protein kinase	AKT1	1.159	0.046	0.863	0.496	74
Caspase-3	CASP3	1.250	0.021	0.800	0.576	67
Vascular endothelial growth factor A	VEGFA	1.250	0.020	0.800	0.594	66
Epidermal growth factor receptor	EGFR	1.250	0.029	0.800	0.540	66
Interleukin-6	IL6	1.261	0.024	0.793	0.578	65
Tumor necrosis factor	TNF	1.261	0.023	0.793	0.572	65
Transcription factor AP-1	JUN	1.284	0.020	0.779	0.599	64
Catenin beta-1	CTNNB1	1.295	0.020	0.772	0.594	63

ASPL: average shortest path length; BC: betweenness centrality; CC1: closeness centrality; CC2: clustering coefficient.