High Expression of Ubiquitin-Specific Protease 39 and Its Roles in Prognosis in Patients with Hepatocellular Carcinoma

Table 3

Univariate and multivariate Cox regression analyses of correlation between USP39 expression and clinical features.

Characteristics	Total (n)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage (T3/T4 vs. T1/T2)	367	2.540 (1.785–3.613)	<0.001	1.696 (0.231–12.438)	0.603
Pathologic stage (Stage IV/III vs. Stage I/II)	346	2.449 (1.689–3.549)	<0.001	1.197 (0.164–8.733)	0.859
Tumor status (with tumor vs. tumor free)	351	2.361 (1.620–3.441)	<0.001	1.794 (1.196–2.691)	0.005
Gender (male vs. female)	370	0.816 (0.573–1.163)	0.260
Age (>60 vs. ≤ 60)	370	1.248 (0.880–1.768)	0.214
Residual tumor (R1/R2 vs. R0)	341	1.571 (0.795–3.104)	0.194
Histologic grade (G3/G4 vs. G1/G2)	365	1.120 (0.781–1.606)	0.539
Vascular invasion (yes vs. no)	314	1.348 (0.890–2.042)	0.159
USP39 (high vs. low)	370	1.775 (1.250–2.519)	0.001	1.539 (1.038–2.281)	0.032

CI: confidence interval.