Evidence-Based Complementary and Alternative Medicine

Research Article

Long-Term Effect of Zhenzhu Tiaozhi Capsule (FTZ) on Hyperlipidemia: 2-Year Results from a Retrospective Study Using Electronic Medical Records

Table 1

Characteristics of patients in statin and nonstatin groups on index date.


Parameters	General lipid-lowering group (N = 740)	FTZ group (N = 99)	value^a

Clinical characteristics
Age, years (mean (SD))	64.1 (13.61)	61.4 (14.15)	0.019
Male gender, n (%)	374 (50.54%)	57 (57.58%)	0.188

Laboratory examination
FBS, mmol/L (mean (SD))	5.99 (2.25)	6.17 (2.81)	0.570
2hPG, mmol/L (median (IQR))	8.62 (6.57–12.49)	7.70 (6.64–9.77)	0.378
HbA1c, % (mean (SD))	6.57 (1.75)	6.40 (1.82)	0.507
TC, mmol/L (mean (SD))	5.38 (1.43)	5.12 (1.57)	0.166
TG, mmol/L (median (IQR))	1.94 (1.30–2.92)	1.50 (0.99–2.29)	0.002
LDL, mmol/L (median (IQR))	3.00 (2.26–3.97)	2.84 (2.20–3.51)	0.398
HDL, mmol/L (mean (SD))	1.20 (0.32)	1.29 (0.39)	0.159
ALT, mmol/L (median (IQR))	18.00 (14.00–27.00)	21.00 (14.15–26.50)	0.862
AST, mmol/L (median (IQR))	21.00 (16.00–27.00)	20.00 (17.00–24.00)	0.398
Cr, μmol/L (median (IQR))	75.00 (62.00–88.00)	65.50 (57.00–83.00)	0.020
BUN, mmol/L (median (IQR))	5.49 (4.54–6.75)	5.14 (4.40–5.84)	0.114

Comorbidities
T2DM, n (%)	286 (38.65%)	48 (48.48%)	0.060
Fatty liver, n (%)	216 (29.19%)	37 (37.37%)	0.096
CHD, n (%)	248 (33.51%)	61 (61.62%)	<0.001
Hypertension, n (%)	477 (64.46%)	72 (72.73%)	0.104
AS, n (%)	414 (55.95%)	60 (60.61%)	0.380
Lipid-lowering treatments
Statins	572 (77.30%)	—	—
Fibrates	114 (15.40%)	—	—
Xuezhikang	54 (7.30%)	—	—
FTZ	—	99 (100%)	—

FBS, fasting blood sugar; 2hPG, 2-hour postprandial blood glucose; HbA1c, hemoglobin A1c; TC, total cholesterol; TG, total triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ALT, alanine transaminase; AST, aspartate transaminase; Cr, creatinine; BUN, blood urea nitrogen; T2DM, type 2 diabetes mellitus; CHD, coronary heart disease; AS, arteriosclerosis; FTZ, Zhenzhu Tiaozhi capsule; IQR, interquartile range. ^a values were calculated by the t-test (normal distribution) or Kruskal–Wallis rank-sum test (nonnormal distribution) for continuous variables and χ² tests or Fisher’s exact test for categorical data.