Phytochemistry and Pharmacology of Thymus broussonetii Boiss

Table 3

Antifungal activity of T. broussonetii.

Used parts	Extracts	Used methods	Tested strains	Key results	References
Aerial parts	Essential oil	Agar disc diffusion; Broth microdilution method	Candida albicans	Ф = 50.00 ± 1.00 mm	[20]
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida krusei	Ф = 49.67 ± 1.53 mm
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida glabrata	Ф = 49.33 ± 1.53 mm
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida parapsilosis	Ф = 51.17 ± 0.76 mm
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
	Essential oil	Agar disc diffusion; Broth microdilution method	Candida albicans	Ф = 50.00 ± 1.00 mm	[13]
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida krusei	Ф = 49.67 ± 1.53 mm
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida glabrata	Ф = 49.33 ± 1.53 mm
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida parapsilosis	Ф = 51.17 ± 0.76 mm
				MIC = 0.45 mg/mL
				MMC = 0.45 mg/mL
			Candida albicans	Ф = 49.67 ± 1.15 mm
				MIC = 0.46 mg/mL
				MMC = 0.46 mg/mL
			Candida krusei	Ф = 47.33 ± 1.53 mm
				MIC = 0.46 mg/mL
				MMC = 0.46 mg/mL
			Candida glabrata	Ф = 48.50 ± 0.50 mm
				MIC = 0.46 mg/mL
				MMC = 0.46 mg/mL
			Candida parapsilosis	Ф = 50.00 ± 1.00 mm
				MIC = 0.46 mg/mL
				MMC = 0.46 mg/mL
Aerial parts	Essential oil	Agar diffusion method; macrodilution broth method	Candida albicans	Ф = 38.5 ± 0.70 mm	[18]
				MIC = 0.25 μg/mL
Aerial parts	Essential oil	Agar diffusion method	Candida albicans	Slightly more sensitive in presence of 0.2% oil	[34]
			Aspergillus niger	Lower sensitivity relatively resistant
Aerial parts	Essential oil	Agar diffusion method	Saccharomyces cerevisiae	MIC = 3%	[16]
			Candida albicans	MIC = 3%
			Zygorrhynchussp	MIC = 4%
			Aspergillus niger	MIC = 3%
Aerial part	Essential oil	Agar disk diffusion method; Broth microdilution method	Candida albicans	Ф = 35.67 ± 0.33 mm	[26]
				MIC = ND
				MBC = ND
			Aspergillus brasiliensis	Ф = ND
				MIC = ND
				MBC = ND