Phytochemistry and Pharmacology of Thymus broussonetii Boiss

Table 6

Other pharmacological activities of T. broussonetii.

Activities	Used parts	Extracts	Experimental approaches	Key results	References
Anti-inflammatory activity	Leaves	n-hexane	Croton oil ear test in mice; inhibition of the croton oil-induced ear edema in mice	Edema reduction = 9%	[28]
		Chloroform		Edema reduction = 47%
		Chloroform + methanol		Edema reduction = 16%
		Methanol		Edema reduction = -5%
Anticorrosive activity	Aerial parts	Essential oils	Loss measurements and electrochemical techniques	82.35% inhibition efficiency at a dose of 2 g/L	[23]
Insecticidal activity	Aerial parts	Essential oils	Fourth instar larvae of Culex pipiens	LC50 = 0.23	[19]
Antiparasitic activity	Aerial parts	Essential oils	Oral administration (20 g/animal) at the time of infection and thereafter for several days	Absence of intracerebral cysts; No anomalies	[30]
Antipyretic activity	Stem	Water, butanol, and ethyl acetate	Yeast-induced fever in rats	Significantly reduced the temperature in febrile rats	[37]
Acute toxicity	Aerial parts	Essential oils	Swiss mice (25–35 g)	LD50 = 2.66 g/kg	[22]
Antinociceptive activity	Leaves and stem	Water	Chemical and thermal models (in vivo)	Writhing inhibition = 88.9%	[31]
		Ethyl acetate and butanol		Writhing inhibition = 69%
				Writhing inhibition = 62.8%
Insecticidal activity	Aerial parts	Essential oils	Effect against adults of Tribolium castaneum herbst	LD50 = 0.08 μl/cm^2; LD90 = 0.19 μl/cm^2	[29]
Insecticidal activity	Aerial parts	Essential oils	Effect against Tribolium castanum pest foodstuffs	TL50 = 1.5 μl/cm^2	[27]
Immunological and behavioral activities	Leaves and stem	Water, butanol, and ethyl acetate	Tested the neurostimulant effects of the extracts	Increased (in vivo) the number of leukocyte categories studied	[31]