Ginsenoside Rg1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice via Activating ERα-Regulating YAP Expression

<div>Liver injury and YAP expression profile in murine hepatic IRI mice subjected to 90 minutes of ischemia and then sacrificed after 1 h, 3 h, 6 h, 12 h, and 24 h after reperfusion. (a) Dynamic changes of Yap expression in mouse liver were detected by PCR and WB, n = 3. (b) Dynamic changes of ALT level, n = 6. (c) HE staining (×200; scale bar: 50 μm). Data are expressed in mean ± SEM; ∗∗∗P &lt; 0.001, ∗∗∗∗P &lt; 0.0001, versus sham group; NS, nonsignificant.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 2: Ginsenoside Rg1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice via Activating ERα-Regulating YAP Expression