Ginsenoside Rg1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice via Activating ERα-Regulating YAP Expression

Figure 3

YAP activation attenuated oxidative stress and liver injury in hepatic IRI. (a) MitoSOX red mitochondrial superoxide indicator detection, n = 6. (b) Mitochondrial JC-1 fluorescence expression, n = 6. (c) ATP content, n = 6. (d) Relative mRNA and protein expression of Yap, n = 3. (e) The changes of serological ALT, n = 6. (f) HE staining (×200; scale bar: 50 μm). Data are expressed in mean ± SEM; ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗P < 0.0001, versus sham group; ^##P < 0.01, ^####P < 0.0001, versus Doxy group; ^△△△△P < 0.001, ^△△△△P < 0.0001, versus IR group.

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