Ginsenoside Rg1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice via Activating ERα-Regulating YAP Expression

Figure 5

Ginsenoside Rg1 activates ERα, upregulates Yap expression, and alleviates IR-mediated liver injury. IR mice were subjected to 90 min of ischemia and reperfusion for 6 h. (a) Mitochondrial ROS content, n = 6. (b) The mitochondrial JC-1 membrane potential of mouse liver, n = 6. (c) The content of ATP, n = 6. (d) The expression of ERα and Yap at the level, n = 3. (e) The ALT level, n = 6. (f) HE staining of liver tissue (×200; scale: 50 μm). Data are expressed in mean ± SEM; ^∗∗P < 0.01, ^∗∗∗∗P < 0.0001, versus sham group; ^#P < 0.05, ^####P < 0.0001, versus IR group; ^△△△△P < 0.0001, versus E2 group.

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