In Vivo Antimalarial Activity of Polyalthia longifolia (Annonaceae) Leaf Extract and Assessment of Its Formulated Oral Dosage Forms

Table 4

Antiplasmodial curative test of PLE in P. berghei passaged mice.

Groups	Dose (mg/kg)	Mean ± SEM
		Level of parasitaemia		% suppression
		Day 3	Day 7
I	NI	0.00	0.00	—
II	NC	20.36 ± 1.94	62.40 ± 8.38	—
III	100	30.18 ± 6.19	25.72 ± 0.38^a∗	58.78
IV	300	29.32 ± 5.32	21.60 ± 2.49^a∗	65.38
V	500	21.86 ± 1.51	17.88 ± 2.35^a∗	71.35
VI	100 (Artesunate)	18.38 ± 0.74	4.30 ± 0.41^a∗	93.11

Results are presented as mean ± SD; n = 6. . Values are compared to negative control; ^a values are compared to day 3. NI = normal control, NC = untreated group, and NA=not applicable.