In Vivo Antimalarial Activity of Polyalthia longifolia (Annonaceae) Leaf Extract and Assessment of Its Formulated Oral Dosage Forms

Table 5

Effect of PLE on liver status of P. berghei passaged mice.

Tests	Groups
	I	II	III	IV	V	VI
AST (U/L)	51 ± 1.009^a	220 ± 1.10 0	80 ± 1.030^a	73 ± 1.070^a	65 ± 1.008^a	59 ± 0.5000^a
ALT (U/L)	40 ± 1.000^a	120 ± 0.500	50 ± 0.500^a	40 ± 1.000^a	45 ± 0.500^a	40 ± 1.000^a
ALK phosphate (U/L)	113 ± 0.500^a	174 ± 1.000	124 ± 0.500^a	108 ± 1.000^a	116 ± 1.000^a	108 ± 0.500^a
Bilirubin (total) (umol/L)	7.6 ± 0.150^a	16.5 ± 0.300	13.3 ± 0.150^a	12.7 ± 0.300^a	10.4 ± 0.200^a	9.6 ± 0.150^b
Bilirubin (direct) (umol/L)	0.1 ± 0.050^a	0.6 ± 0.040	0.2 ± 0.055^a	0.2 ± 0.030^a	0.1 ± 0.035^a	0.1 ± 0.015^a
Total protein (g/L)	56 ± 0.500^a	22 ± 1.000	51 ± 1.000^a	68 ± 0.500^a	66 ± 1.450^a	67 ± 0.900^a
Albumin (g/L)	45 ± 1.000^a	17 ± 0.500	29 ± 0.500^a	37 ± 1.00^a	37 ± 0.500^a	29 ± 0.450^a
Globulin (g/L)	30 ± 0.500^a	16 ± 0.650	34 ± 0.650^a	32 ± 0.700^a	39 ± 0.700^a	38 ± 0.600^a

Results are presented as mean ± SD (n = 6) of triplicate determinations; mean values with different letters as superscript in column where “a” is considered significant at and “b” is considered significant at .