Research Article

Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer

Figure 4

Combination of cinobufotalin and gefitinib induced ROS accumulation and suppressed the expression of HGF and c-Met. (a) ROS production was increased after combined treatment with cinobufotalin and gefitinib. (b) A549 cells were analyzed for HGF and c-Met protein expression by Western blot. (c) c-Met gene expression was determined by real-time quantitative PCR. , , , and vs. the control group; ## and #### vs. the gefitinib group. The experiment was repeated three times.
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