Therapeutic Efficacy and Safety of Safflower Injection in the Treatment of Acute Coronary Syndrome

Table 1

Characteristics of the included studies.

Study ID	Number (E/C)	Gender (E/C)	Intervention	Control (conventional treatment)	SFI dosage	Duration	Outcome measures
Cao et al. [21]	60/60	67/53	SFI + control	Aspirin and nitroglycerin	20 mL, q.d.	14 days	TER and ECG improvement
Zheng [22]	30/28	38/20	SFI + control	Aspirin, nitroglycerin, metoprolol, ACEI, isosorbide dinitrate, etc.	20 mL, q.d.	10 days	TER
Hang [23]	104/96	123/77	SFI + control	Aspirin, nitrates, ACEI, statins, metoprolol, etc.	20 mL, q.d.	10 days	TER and ECG improvement
Ding and Dong [24]	20/16	22/14	SFI + control	Aspirin, nitrates, ACEI, etc.	20 mL, q.d.	14 days	HR indexes
Du [25]	30/30	34/26	SFI + control	Aspirin, nitrates, β-blockers, calcium antagonists, etc.	20 mL, b.i.d.	10 days	TER and HR indexes
Zhang and Zhao [26]	60/60	80/40	SFI + control	Aspirin, isosorbide dinitrate, metoprolol, etc.	20 mL, q.d.	14 days	TER and HR indexes
Jin et al. [27]	44/40	51/33	SFI + control	Aspirin, isosorbide mononitrate, statins, low molecular heparin, etc.	40 mL, q.d.	14 days	TER
Zhang [28]	41/41	54/28	SFI + control	Aspirin, nitrates, β-blockers, calcium antagonists, etc.	20 mL, q.d.	15 days	TER and ECG improvement
Ma [29]	80/60	73/67	SFI + control	Aspirin and nitrates	20 mL, q.d.	15 days	TER, HR indexes, and ECG improvement
Wang et al. [30]	36/36	43/29	SFI + control	Aspirin, nitrates, calcium antagonists, etc.	20 mL, q.d.	14 days	TER and HR indexes
Yan [31]	70/70	82/58	SFI + control	Aspirin, isosorbide mononitrate, simvastatin, etc.	30 mL, q.d.	14 days	TER and ECG improvement
Zhu et al. [32]	32/28	45/15	SFI + control	Aspirin, nitrates, clopidogrel, statins, low molecular heparin, etc.	40 mL, q.d.	14 days	TER and ECG improvement
Chen [33]	46/46	50/42	SFI + control	Aspirin, atorvastatin, etc.	20 mL, q.d.	14 days	TER and ARs
Cao [34]	39/39	47/31	SFI + control	Aspirin, atorvastatin, β-blockers, etc.	20 mL, q.d.	15 days	LVEF
Zhang [35]	98/98	103/93	SFI + control	Aspirin, isosorbide mononitrate, ACEI, calcium antagonists, etc.	20 mL, q.d.	14 days	TER and HR indexes
Zhao et al. [36]	42/40	45/37	SFI + control	Aspirin, simvastatin, clopidogrel, etc.	15 mL, q.d.	28 days	TER, HR indexes, LVEF, and ARs

E, experimental group; C, control group; SFI, safflower injection; ACEI, angiotensin-converting enzyme inhibitors; q.d., once a day; b.i.d., twice a day; TER, total effective rate; ECG, electrocardiogram; HR, hemorheology; LVEF, left ventricular ejection fraction; AR, adverse reactions.