Water-Soluble Total Flavonoids Isolated from Isodon lophanthoides var. gerardianus (Benth.) H. Hara Promote Hepatocellular Carcinoma Sensitivity to 5-Fluorouracil

Table 1

Cytotoxicity of WSTF against normal human cells and tumor cells.

Cells	Time (h)	IC50 (mg/mL)
HepG2	24	0.52 ± 1.56
	48	0.42 ± 1.33
	72	0.36 ± 0.96
	24	0.73 ± 1.43
SMMC-7721HCC	48	0.59 ± 2.62
	0.40 ± 0.76

Cells (5 × 10⁴ (ml)) were subjected to WSTF treatment at different doses under 37°C and 5% CO₂ conditions for 24, 48, and 72 h, respectively. The cytotoxicity of WSTF was determined through MTT assay, which was presented in the manner of 50% inhibitory concentration (IC₅₀). Data in each typical experiment were obtained from 3 independent tests.