Water-Soluble Total Flavonoids Isolated from Isodon lophanthoides var. gerardianus (Benth.) H. Hara Promote Hepatocellular Carcinoma Sensitivity to 5-Fluorouracil

Table 2

Effect of WSTF plus 5-FU on HepG2 cells.

Combination		Drug alone				DRI
WSTF (mg/mL)	5-FU (μM)	WSTF (mg/mL)	5-FU (μM)	Fa	CI	WSTF (mg/mL)	5-FU (μM)
0	0	0	0
0.125	2.5	0.40 ± 0.14	7.20 ± 0.52	0.26 ± 0.02	0.66 ± 0.15	3.16 ± 0.62	2.88 ± 0.38
0.25	5	0.91 ± 0.34	17.58 ± 3.34	0.48 ± 0.05	0.56 ± 0.17	3.65 ± 0.77	3.52 ± 0.87
0.50	10	1.88 ± 0.63	38.00 ± 4.84	0.68 ± 0.08	0.53 ± 0.14	3.76 ± 0.95	3.80 ± 0.85
1.00	20	5.49 ± 1.03	119.42 ± 6.37	0.88 ± 0.09	0.35 ± 0.06	5.49 ± 1.34	5.97 ± 0.94
2.00	40	15.32 ± 2.32	357.37 ± 33.72	0.96 ± 0.07	0.24 ± 0.08	7.66 ± 1.26	8.93 ± 1.04

Fa is the fraction affected by the dose.