The Effect of Long-Term Duration Renal Replacement Therapy on Outcomes of Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study

Table 3

Baseline characteristics for critically ill patients at 28-day mortality.

Variables	Total (n = 506)	Death (n = 168)	Alive (n = 338)	value
Age, years	64 (52, 74)	66 (52, 76)	63 (50, 73)	0.056
Male, n (%)	306 (60.5%)	116 (69%)	190 (56.2%)	0.005
Heart rate, beats/min	106 ± 23	108 ± 23	105 ± 23	0.376
Mean arterial pressure, mmHg	55 (49, 63)	53 (46, 62)	56 (50, 63)	0.005
Respiratory rate, breath/min	28 (24, 34)	29 (24, 35)	28 (24, 33)	0.081
Creatinine admitted to ICU, mg/dL	2.9 (1.8, 4.4)	2.9 (2, 4.6)	2.7 (1.6, 4.3)	0.119
Creatinine in 24 hours before RRT initiation, mg/dL	4.2 (3, 5.5)	4.2 (3.1, 5.6)	4.1 (2.9, 5.5)	0.449
Duration of RRT, hours	105.8 (63.7, 189.8)	88.3 (53.4, 148.5)	116.8 (70.06, 217.6)	<0.001
RRT modes, n (%)
CVVH	14 (2.7%)	4 (2.4%)	10 (2.9%)	0.709
CVVHD	160 (31.6%)	59 (35.1%)	101 (29.9%)	0.233
CVVHDF	223 (44.1%)	69 (41.1%)	154 (45.6%)	0.338
CVVH + CVVHD	88 (17.4%)	30 (17.8%)	58 (17.1%)	0.845
CVVH + CVVHDF	12 (2.4%)	4 (2.4%)	8 (2.4%)	0.992
CVVHD + CVVHDF	8 (1.6%)	2 (1.2%)	6 (1.8%)	1
Others	1 (0.2%)	0	1 (0.3%)	1
Main diagnosis class, n (%)
Cardiovascular	105 (20.8%)	32 (19%)	73 (21.6%)	0.505
Trauma	63 (12.4%)	21 (12.5%)	42 (12.4%)	0.981
Respiratory	20 (4%)	7 (4.2%)	13 (3.8%)	0.862
Infection	124 (24.5%)	41 (24.4%)	83 (24.6%)	0.984
Others	194 (38.3%)	67 (39.9%)	127 (37.6%)	0.615
Sepsis, n (%)	95 (18.8%)	34 (20.2%)	61 (18%)	0.552
Chronic kidney disease, n (%)	176 (34.8%)	56 (33.3%)	120 (35.5%)	0.629
Simplified Acute Physiology Score II	52.8 ± 14.6	55.1 ± 14.9	51.6 ± 14.4	0.717
SOFA	10 (7, 13)	11 (8, 13)	9 (7, 12)	0.009
Charlson comorbidity index	5 (3, 6)	5 (3, 7)	4 (2, 6)	0.003
Mechanical ventilation, n (%)	461 (91.1%)	154 (91.7%)	307 (90.8%)	0.755

RRT = renal replacement therapy; CVVH = continuous venovenous hemofiltration; CVVHD = continuous venovenous hemodialysis; CVVHDF = continuous venovenous hemodiafiltration.