Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD⁺/SIRT3/Mitochondrial Dynamics Pathway

Figure 5

Effect of JPYSF on the QPRT/NAD⁺/SIRT3 pathway in the kidney of CKD rats. The levels of NAD⁺ (a) and quinolinic acid (b) in each group in the setting of 5/6 Nx-induced CKD. The levels of NAD⁺ (c) and quinolinic acid (d) in each group in the setting of adenine-induced CKD. Representative Western blot images (e) and densitometric analyses (f) of QPRT and SIRT3 protein expression in the setting of 5/6-Nx induced CKD. Representative Western blot images (g) and densitometric analyses (h) of QPRT and SIRT3 protein expression in the setting of adenine-induced CKD. All proteins expression was normalized to β-actin content. Data are presented as the means ± SEM, n = 6 rats per group ( compared with the sham or the control group; compared with the 5/6 Nx-CKD or the adenine-CKD group; compared with the 5/6 Nx-CKD or the adenine-CKD group; compared with the adenine-CKD group).

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