Huangkui Capsule Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Macrophage Activation by Suppressing Inflammation and Oxidative Stress in Mice

Figure 2

Effect of HKC on the inflammatory response in lung tissues. Histopathological changes in the lung tissues (100x, H&E staining). Mice were intragastrically administered HKC once daily for 5 days. DEX (5 mg/kg) was intraperitoneally injected once 30 min before LPS instillation. Lungs were processed for histological changes (a) 24 h after LPS challenge. Lung injury scores (b) were evaluated. BALF was collected 24 h after LPS instillation to analyse the total cell count (c) and neutrophil count (d). Lung homogenates were prepared 24 h after LPS exposure, and the activity of MPO (e) was determined. Data represent means ± SD (n = 6).  < 0.05.  < 0.01.

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