Dahuang Danshen Decoction Inhibits Pancreatic Fibrosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

<div>Decoction of DD ameliorated DDC-induced oxidative stress injury by regulating the Keap-1 pathway <i>in vivo</i>. (a) GSH content in serum. (b) MDA content in serum. (c) SOD in serum. (d) Pancreatic ROS levels were measured. (e) Pancreatic levels of Keap-1, HO-1, NQO1, and Nrf2 proteins were determined by WB. (f) Pancreatic mRNA level of NQO1. (g) Pancreatic mRNA level of GPX1. (h) Pancreatic mRNA level of HO-1. (i) Pancreatic mRNA level of GST-<i>π</i>. Data in (f)–(i) were determined by qRT-PCR. 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Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Dahuang Danshen Decoction Inhibits Pancreatic Fibrosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress 