Uncovering the Mechanism of Curcuma in the Treatment of Ulcerative Colitis Based on Network Pharmacology, Molecular Docking Technology, and Experiment Verification

Table 2

Information on potential targets and the topological attributes.

No.	Gene name	Protein name	UniProt ID	Degree
1	AKT1	AKT serine/threonine kinase 1	P31749	43
2	EGFR	Epidermal growth factor receptor	P00533	35
3	TNF	Tumor necrosis factor	P01375	35
4	STAT3	Signal transducer and activator of transcription 3	P40763	33
5	PTGS2	Prostaglandin-endoperoxide synthase 2	P35354	32
6	MMP9	Matrix metallopeptidase 9	P50281	31
7	ESR1	Estrogen receptor 1	P03372	25
8	EP300	E1A-binding protein P300	Q09472	23
9	TLR4	Toll-like receptor 4	O00206	23
10	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	20
11	SERPINE1	Serpin family E member 1	P05121	18
12	CDK4	Cyclin-dependent kinase 4	P11802	14
13	NR3C1	Nuclear receptor subfamily 3 group C member 1	P04150	14
14	CDK1	Cyclin-dependent kinase 1	P06493	13
15	CDK2	Cyclin-dependent kinase 2	P24941	13
16	MMP3	Matrix metallopeptidase 3	P08254	13
17	ADAM17	ADAM metallopeptidase domain 17	P78536	12
18	CHEK1	Checkpoint kinase 1	O14757	12
19	LCK	LCK proto-oncogene, Src family tyrosine kinase	P06239	12
20	MMP13	Matrix metallopeptidase 13	P45452	12
21	CXCR2	C-X-C motif chemokine receptor 2	P25025	11
22	MMP14	Matrix metallopeptidase 14	P50281	11
23	MMP7	Matrix metallopeptidase 7	P09237	11
24	RPS6KB1	Ribosomal protein S6 kinase B1	P23443	11
25	CA9	Carbonic anhydrase 9	Q16790	10
26	NOS2	Nitric oxide synthase 2	P22894	10
27	PTGS1	Prostaglandin-endoperoxide synthase 1	P23219	10
28	TLR9	Toll-like receptor 9	Q9NR96	10
29	ALOX5	Arachidonate 5-lipoxygenase	P09917	9
30	MET	MET proto-oncogene, receptor tyrosine kinase	P08581	9
31	MMP8	Matrix metallopeptidase 8	P22894	9
32	RAF1	Raf-1 proto-oncogene, serine/threonine kinase	P04049	9
33	AURKA	Aurora kinase A	O14965	8
34	BCL2	BCL2 apoptosis regulator	P10415	8
35	ESR2	Estrogen receptor 2	Q92731	8
36	F3	Coagulation factor III, tissue factor	P13726	8
37	MIF	Macrophage migration inhibitory factor	P14174	8
38	NFE2L2	Nuclear factor, erythroid 2 like 2	P09237	8
39	TOP1	DNA topoisomerase I	P11387	8
40	ALOX15	Arachidonate 15-lipoxygenase	P16050	7
41	DPP4	Dipeptidyl peptidase 4	P27487	7
42	PTPN2	Protein tyrosine phosphatase nonreceptor type 2	P17706	7
43	ABCC1	ATP binding cassette subfamily C member 1	P33527	6
44	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	6
45	VDR	Vitamin D receptor	P11473	6
46	CYP2C19	Cytochrome P450 family 2 subfamily C member 19	P33261	5
47	BRAF	B-Raf proto-oncogene, serine/threonine kinase	P15056	3
48	HTR1A	5-Hydroxytryptamine receptor 1A	P08908	3
49	RORC	RAR-related orphan receptor C	P51449	3
50	SLC6A4	Solute carrier family 6 member 4	P31645	3
51	TYR	Tyrosinase	P14679	3
52	NR1H2	Nuclear receptor subfamily 1 group H member 2	P55055	2
53	PTGER2	Prostaglandin E receptor 2	P43116	2
54	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1	P28845	2