Network Pharmacology-Based Approach to Comparatively Predict the Active Ingredients and Molecular Targets of Compound Xueshuantong Capsule and Hexuemingmu Tablet in the Treatment of Proliferative Diabetic Retinopathy

Table 2

Genes/pathways mentioned in the discussion and whether CXC/HXMMT regulates their functions.

Genes/pathways	Role in PDR	CXC regulates?	HXMMT regulates?
Bcl-2, Bcl-2-associated X, and caspase-3	Apoptosis and neuroprotective effects	Yes [14]	Unknown
VEGF, ICAM-1, ET-1, PEDF, and occludin	Erythrocyte aggregation, plasma viscosity, acellular vessel, and pericyte loss	Yes [20, 21]	Unknown
PPAR signaling pathway	Protective effects	Unknown	Unknown
YAP	Protecting retinal vascular endothelial cells	Yes [6]	Unknown
MMP9 and IGF-1	Regulating retinal capillary cell apoptosis/neovascularization	Unknown	Unknown
APOD	Neovascularization	Unknown	Unknown
PECAM1	Maintenance of human vascular endothelial barrier integrity	Unknown	Unknown
YWHAB	Performing specific functions in rod photoreceptors	Unknown	Unknown
RACK1	Neovascularization	Unknown	Unknown
PARP1	Inflammation, cell death, and retinal disease progression	Unknown	Unknown
AGE-RAGE signaling pathway	Neovascularization/neuroprotection	Unknown	Unknown
Circular RNA COL1A2/miR-29b/VEGF	Neovascularization	Unknown	Unknown
VEGF/PI3K-Akt signaling pathway	Neovascularization	Unknown	Unknown
TNF signaling pathway	Inflammation	Unknown	Unknown

PDR, proliferative diabetic retinopathy; CXC, compound Xueshuantong capsule; HXMMT, Hexuemingmu tablet.