Evidence-Based Complementary and Alternative Medicine

Research Article

Network Pharmacology Analysis of Traditional Chinese Medicine Formula Shuang Di Shou Zhen Tablets Treating Nonexudative Age-Related Macular Degeneration

Table 2

Enrichment analysis of candidate targets for SDSZT against dry AMD.


GO	Description	Count	Log10(P)	Hits

hsa05200	Pathways in cancer	52	−58.12	AKT1\|AKR1B1\|AR\|BAX\|CCND1\|BCL2\|CASP3\|CASP7\|CASP8\|CDK2\|CDKN1A\|CTNNB1\|NQO1\|E2F1\|E2F2\|EDN1\|EGF\|EGFR\|ERBB2\|ESR1\|F2\|FOS\|GSTM1\|GSTP1\|HIF1A\|HMOX1\|HSP90AA1\|IFNG\|IGF2\|IL2\|IL4\|IL6\|CXCL8\|JUN\|MDM2\|MMP2\|MMP9\|MYC\|NFE2L2\|NOS2\|PPARD\|MAPK1\|MAPK8\|PTEN\|PTGS2\|RAF1\|RB1\|RELA\|STAT1\|TGFB1\|TP53\|VEGFA

ko05418	Fluid shear stress and atherosclerosis	31	−45.9	AKT1\|BCL2\|CAV1\|MAPK14\|CTNNB1\|NQO1\|EDN1\|FOS\|GSTM1\|GSTP1\|HMOX1\|HSP90AA1\|ICAM1\|IFNG\|IL1A\|IL1B\|JUN\|KDR\|MMP2\|MMP9\|NFE2L2\|NOS3\|PLAT\|MAPK8\|RELA\|CCL2\|SELE\|TNF\|TP53\|VCAM1\|VEGFA

hsa05215	Prostate cancer	25	−38.22	AKT1\|AKR1B1\|AR\|CCND1\|BCL2\|CDK2\|CDKN1A\|CTNNB1\|
				E2F1\|E2F2\|EGF\|EGFR\|ERBB2\|GSTP1\|HSP90AA1\|MDM2\|MMP3\|MMP9\|PLAT\|MAPK1\|PTEN\|RAF1\|RB1\|RELA\|TP53

ko04668	TNF signaling pathway	23	−33.56	AKT1\|CASP3\|CASP7\|CASP8\|MAPK14\|EDN1\|FOS\|CXCL2\|ICAM1\|IL1B\|IL6\|CXCL10\|JUN\|MMP3\|MMP9\|MAPK1\|MAPK8\|PTGS2\|RELA\|CCL2\|SELE\|TNF\|VCAM1

hsa05205	Proteoglycans in cancer	24	−27.71	AKT1\|CCND1\|CASP3\|CAV1\|CDKN1A\|MAPK14\|CTNNB1\|EGFR\|ERBB2\|ESR1\|HIF1A\|IGF2\|IL6\|KDR\|MDM2\|MMP2\|MMP9\|MYC\|MAPK1\|RAF1\|TGFB1\|TNF\|TP53\|VEGFA

hsa05210	Colorectal cancer	17	−23.46	AKT1\|BAX\|CCND1\|BCL2\|CASP3\|CDKN1A\|CTNNB1\|EGF\|EGFR\|FOS\|JUN\|MYC\|MAPK1\|MAPK8\|RAF1\|TGFB1\|TP53

hsa04932	Nonalcoholic fatty liver disease	18	−20.48	AKT1\|BAX\|CASP3\|CASP7\|CASP8\|IL1A\|IL1B\|IL6\|CXCL8\|INSR\|JUN\|PPARA\|MAPK8\|PTGS1\|PTGS2\|RELA\|TGFB1\|TNF

ko05144	Malaria	13	−20.39	CD36\|CD40LG\|ICAM1\|IFNG\|IL1B\|IL6\|CXCL8\|IL10\|CCL2\|SELE\|TGFB1\|TNF\|VCAM1

hsa01524	Platinum drug resistance	13	−17.9	AKT1\|BAX\|BCL2\|CASP3\|CASP8\|CDKN1A\|ABCC2\|ERBB2\|GSTM1\|GSTP1\|MDM2\|MAPK1\|TP53

hsa04630	JAK-STAT signaling pathway	14	−14.36	AKT1\|CCND1\|BCL2\|CDKN1A\|EGF\|EGFR\|IFNG\|IL2\|IL4\|IL6\|IL10\|MYC\|RAF1\|STAT1

ko04064	NF-kappa B signaling pathway	11	−13.05	PARP1\|BCL2\|CD40LG\|CXCL2\|ICAM1\|IL1B\|CXCL8\|PTGS2\|RELA\|TNF\|VCAM1

hsa05202	Transcriptional misregulation in cancer	13	−11.96	BAX\|CDKN1A\|IGFBP3\|IL6\|CXCL8\|MDM2\|MMP3\|MMP9\|MPO\|MYC\|PLAT\|RELA\|TP53

hsa04931	Insulin resistance	10	−10.71	AKT1\|CD36\|IL6\|INSR\|NOS3\|PPARA\|MAPK8\|PTEN\|RELA\|TNF

hsa04217	Necroptosis	11	−10.31	PARP1\|BAX\|BCL2\|CASP8\|HSP90AA1\|IFNG\|IL1A\|IL1B\|MAPK8\|STAT1\|TNF

hsa05216	Thyroid cancer	7	−9.87	BAX\|CCND1\|CDKN1A\|CTNNB1\|MYC\|MAPK1\|TP53

hsa04371	Apelin signaling pathway	10	−9.6	AKT1\|CCND1\|NOS2\|NOS3\|SERPINE1\|PIK3CG\|PLAT\|MAPK1\|RAF1\|SPP1

hsa04062	Chemokine signaling pathway	11	−9.45	AKT1\|CXCL2\|CXCL8\|CXCL10\|PIK3CG\|MAPK1\|RAF1\|RELA\|CCL2\|CXCL11\|STAT1

ko05330	Allograft rejection	6	−8.1	CD40LG\|IFNG\|IL2\|IL4\|IL10\|TNF

ko05120	Epithelial cell signaling in Helicobacter pylori infection	7	−8.11	CASP3\|MAPK14\|EGFR\|CXCL8\|JUN\|MAPK8\|RELA

ko00380	Tryptophan metabolism	6	−8.03	CAT\|CYP1A1\|CYP1A2\|CYP1B1\|MAOA\|MAOB