Shenlijia Attenuates Doxorubicin-Induced Chronic Heart Failure by Inhibiting Cardiac Fibrosis

<div>SLJ upregulates the expression of TIMP-1, TIMP-2, and TIMP-3 and downregulates that of MMP-13: (a–d) representative immunohistochemical image analyses of MMP-13, TIMP-1, TIMP-2, and TIMP-3 protein expressions; (e–h) western blot analysis of MMP-13, TIMP-1, TIMP-2, and TIMP-3 protein expressions in myocardium. <i>n</i> = 8. <svg height="10.7395pt" id="M14" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 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287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the CHF group. SJL, Shenlijia; TIMP, metalloproteinase inhibitor; MMP, matrix metalloproteinase; and CHF, chronic heart failure.</div>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Shenlijia Attenuates Doxorubicin-Induced Chronic Heart Failure by Inhibiting Cardiac Fibrosis 