Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach
Table 3
Gene ontology terms of the biological process category associated with Soyang type.
PANTHER GO-Slim biological process term
Number of genes
valued
Combined scoree
Reference lista
Target listb
Expectedc
Cellular metabolic process (GO:0044237)
1744
84
32.73
7.02E − 16
230.1149
Drug metabolic process (GO:0017144)
127
23
2.38
5.71E − 13
226.2333
Fatty acid metabolic process (GO:0006631)
138
20
2.59
2.50E − 11
144.3277
Response to chemical (GO:0042221)
576
39
10.81
9.88E − 10
141.426
Response to xenobiotic stimulus (GO:0009410)
40
12
0.75
4.88E − 08
123.8619
Cofactor metabolic process (GO:0051186)
159
19
2.98
1.32E − 07
107.5996
Cellular lipid metabolic process (GO:0044255)
294
25
5.52
3.47E − 07
103.8276
Carbohydrate metabolic process (GO:0005975)
185
20
3.47
5.99E − 07
103.5943
Ammonium ion metabolic process (GO:0097164)
34
10
0.64
1.28E − 06
92.36633
Nitrogen compound metabolic process (GO:0006807)
38
10
0.71
1.41E − 06
85.06531
aNumber of genes in the reference list that map to this PANTHER classification category. bNumber of genes in the target gene list that map to this PANTHER classification category. cThe expected value is the number of genes that can be expected in the target gene list for this PANTHER category based on the reference list. d values are determined by binomial statistics with Benjamini–Hochberg corrections. eCombined score is computed by taking the log of the value and multiplying that by the Z-score of the deviation from the expected rank.
