Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Figure 1

Effects of the methanol/methylene chloride extract of V. cienkowskii on arterial pressure and heart rate. Each bar represents the mean ± SEM; n = 5;  < 0.01 significant difference compared to control (rats receiving distilled water); ^$$ < 0.01 significant difference compared to hypertensive control (rats receiving L-NAME only); L-NAME + CAPT: rat treated with L-NAME and captopril at the dose of 25 mg/kg; L-NAME + MMVC (200 mg/kg): rats treated with L-NAME and plant extract (MMVC) at the dose of 200 mg/kg; L-NAME + MMVC (400 mg/kg): rats treated with L-NAME and plant extract (MMVC) at the dose of 400 mg/kg; SAP: systolic arterial pressure (a); DAP: diastolic arterial pressure (b); MAP: mean arterial pressure (c); HR: heart rate (d).

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