Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Table 2

Effects of the methanol/methylene chloride extract of V. cienkowskii on hepatic and renal markers.

Parameters		Distilled water	L-NAME	L-NAME + CAPT	L-NAME + MMVC (200 mg/kg)	L-NAME + MMVC (400 mg/kg)
ASAT (U/L)	Serum	31.75 ± 3.45	59.25 ± 3.93	37.46 ± 5.34^$$	30.75 ± 4.18^$$	36.11 ± 1.29^$$
	Liver	132.00 ± 5.45	178.50 ± 9.72	161.21 ± 4.33	160.79 ± 4.64	146.21 ± 5.70^$$
ALAT (U/L)	Serum	15.89 ± 0.89	26.21 ± 1.35	17.71 ± 0.69^$$	18.14 ± 0.97^$$	18.07 ± 1.14^$$
	Liver	68.64 ± 4.95	96.46 ± 1.86	77.96 ± 2.46^$$	76.00 ± 1.13^$$	75.89 ± 5.09^$$
Bilirubin (mg/dL)	Serum	1.90 ± 0.18	2.32 ± 0.09	1.97 ± 0.14	1.85 ± 0.14	1.35 ± 0.11
	Liver	7.28 ± 0.25	8.04 ± 0.40	7.50 ± 0.59	7.26 ± 0.35	6.42 ± 0.25
Creatinine (mg/L)	Serum	26.50 ± 2.48	48.00 ± 3.80	36.25 ± 3.38^$	39.50 ± 3.68	34.50 ± 3.80^$
	Kidneys	20.50 ± 1.51	39.25 ± 2.31	21.75 ± 1.35^$	21.50 ± 4.32^$	19.00 ± 1.50^$

Each data represent the mean ± SEM; n = 5;  < 0.05;  < 0.01 significant differences compared to control (rats receiving distilled water); ^$ < 0.05; ^$$ < 0.01 significant differences compared to hypertensive control (rats receiving L-NAME only); L-NAME  +  CAPT: rats treated with L-NAME and captopril at the dose of 25 mg/kg; L-NAME  +  MMVC (200 mg/kg): rats treated with L-NAME and plant extract (MMVC) at the dose of 200 mg/kg; L-NAME  +  MMVC (400 mg/kg): rats treated with L-NAME and plant extract (MMVC) at the dose of 400 mg/kg.