Antihypertensive Effects of the Vitex cienkowskii (Verbenaceae) Stem-Bark Extract on L-NAME-Induced Hypertensive Rats

Table 3

Effects of the methanol/methylene chloride extract of V. cienkowskii on lipid profile.

Parameter	Distilled water	L-NAME	L-NAME + CAPT	L-NAME + MMVC (200 mg/kg)	L-NAME + MMVC (400 mg/kg)
T Chol (mg/dL)	110.15 ± 11.22	156.95 ± 14.90	144.99 ± 8.79	128.09 ± 6.03	89.74 ± 6.46^$$
TG (mg/dL)	155.00 ± 14.20	190.83 ± 10.88	116.25 ± 11.42^$$	108.33 ± 11.32^$$	90.83 ± 8.03^$$
HDL Chol (mg/dL)	60.76 ± 2.93	30.50 ± 3.15	54.90 ± 7.37^$$	62.87 ± 4.83^$$	56.77 ± 2.61^$$
LDL Chol (mg/dL)	49.38 ± 10.26	126.45 ± 14.40	90.09 ± 12.58	65.2 ± 8.02^$$	32.9 ± 6.05^$$
AI	0.81 ± 0.17	4.27 ± 0.57	1.84 ± 0.42^$$$	1.08 ± 0.19^$$$	0.59 ± 0.11^$$$

Each data represent the mean ± SEM; n = 5;  < 0.05;  < 0.01 significant differences compared to control (rats receiving distilled water);  < 0.001 significant differences compared to control (rats receiving distilled water); ^$$ < 0.01 significant differences compared to hypertensive control (rats receiving L-NAME only); ^$$$p < 0.001 significant differences compared to hypertensive control (rats receiving L-NAME only); L-NAME + CAPT: rats treated with L-NAME and captopril at the dose of 25 mg/kg; L-NAME + MMVC (200 mg/kg): rats treated with L-NAME and plant extract (MMVC) at the dose of 200 mg/kg; L-NAME + MMVC (400 mg/kg): rats treated with L-NAME and plant extract (MMVC) at the dose of 400 mg/kg. T Chol, total cholesterol; TG, triglycerides; AI, atherogenic index.