Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents

<div>Histogram showing different phases of staining MCF7 cells with annexin V FITC/PI treated with vehicle control. Compounds (a) 2, (b) 3, and (c) 7, each in three concentrations, 24 h. <i>X</i>-axis: annexin (V); <i>y</i>-axis: PI. C1: (necrosis death, PI+/annexin V-); C2: (late apoptosis, PI+/annexin V+); C3: (living cells, PI-/annexin V-); C4: (early apoptosis, PI-/annexin V+). Experiment was repeated 2x.</div>

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Figure 3

Figure 3: Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents 