Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents

Table 1

Cytotoxic activity of the verified compounds (2, 3, 4, 5, and 7) (MTT 72 h, IC50 ± SD μM).

Compound	MCF7	A2780	HT29	MRC5
2	0.648 ± 0.087	0.729 ± 0.363	1.343 ± 0.637	7.507 ± 1.510
3	0.150 ± 0.060	0.179 ± 0.010	0.222 ± 0.098	2.027 ± 0.250
4	0.212 ± 0.010	0.456 ± 0.180	0.228 ± 0.075	0.048 ± 0.003
5	0.184 ± 0.052	0.132 ± 0.012	1.048 ± 0.005	0.047 ± 0.042
7	2.120 ± 0.989	3.652 ± 1.939	5.082 ± 0.673	9.076 ± 1.010
Podophyllotoxin	0.004 ± 0.001	0.007 ± 0.001	0.002 ± 0.001	0.043 ± 0.060

Data are representation of three independent experiments (n = 4). Statistical difference (one-way ANOVA, Tukey’s post hoc): , , and were considered significant.