Xiaoyaosan Exerts Therapeutic Effects on the Colon of Chronic Restraint Stress Model Rats via the Regulation of Immunoinflammatory Activation Induced by the TLR4/NLRP3 Inflammasome Signaling Pathway

Figure 6

The effect of Xiaoyaosan on the immunohistochemistry of TLR4, MyD88, NF-κB-p65, TAK1, IRAK1, and TRAF6 in the colon. (a)–(f) Immunohistochemical analysis of TLR4, MyD88, NF-κB-p65, TAK1, IRAK1, and TRAF6 expression in colonic tissue (×200 and ×400 magnification) and quantification of TLR4, MyD88, NF-κB-p65, TAK1, IRAK1, and TRAF6 immunohistochemical staining. Bars represent the means ± SD of 5 rats per group. ^▲ and ^▲▲ vs. the control group; and vs. the model group. TLR4, Toll-like receptor 4; MyD88, myeloid differentiation primary response protein; IRAK1, interleukin 1 receptor-associated kinase1; TAK1, transforming growth factor beta-activated kinase 1; TRAF6, tumor necrosis factor receptor-associated factor 6; NF-κB-p65, nuclear factor kappa beta-p65.

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