The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from <i>Tripterygium</i> Based on Computational Approaches

<div>Interactions between compounds and targets for sesquiterpene pyridine alkaloids from <i>Tripterygium</i>. (a) Compound-target network for 55 sesquiterpene pyridine alkaloids. Octagons are alkaloids, and circles (red) indicated seven categories, like Type 1, Type 3, Type 4, Type 5, Type 6, Type 7, and Type 8. Diamonds (blue) are targets with the node size according to “degree” in the node size mapping. (b) Target-target interaction network for key interacting genes with the node size according to “degree” in the node size mapping.</div>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from <i>Tripterygium</i> Based on Computational Approaches 

Figure 3 | The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from Tripterygium Based on Computational Approaches 