Quyu Shengxin Decoction Alleviates DSS-Induced Ulcerative Colitis in Mice by Suppressing RIP1/RIP3/NLRP3 Signalling

Figure 5

mRNA expression of RIP1 (a), RIP3 (b), Drp1 (c), NLRP3 (d), caspase-1 (e), IL-1β (f), and IL-18 (g) in each group. The mRNA expression was significantly elevated in the DSS group and was the lowest in the control group. Compared with the DSS group, the QYSX group presented significantly lower mRNA levels of RIP1, RIP3, Drp1, NLRP3, caspase-1, IL-1β, and IL-18 (). The mRNA expression of RIP1 and Drp1 was higher in the SX group (^#) and QY group (^##) than that in the QYSX group. Compared with those in the QYSX group, the RIP3 and IL-1β mRNA levels were higher in the SX group (^##) and QY group (^##). There were significant differences in NLRP3 mRNA expression between the QYSX group and the SX group (^##). The mRNA expression of caspase-1 in the QYSX group was lower than that in the SX group (^##), and there were significant differences among the 5-ASA group, the QY group, and the DSS group (^&&). The mRNA expression of IL-18 in the QYSX group was lower than that in the SX group (^&&).

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