Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs

Figure 4

Mean plasma concentration-time curve of hydroxychloroquine (a) and artemisinin (female (b) and male (c)) in rats after oral administration of AH at doses of 146, 219, 328, and 492 mg/kg on day 1 and day 14 during the course of the repeated dose TK study.

(a)

(b)

(c)