Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs

Table 1

Intra- and inter-run precision and accuracy of the method.

Analyte	Concentration (ng/mL)	Precision (RSD, %)				Accuracy (RE, %)
		Intrarun			Inter-run	Intrarun			Inter-run
		Run 1	Run 2	Run 3		Run 1	Run 2	Run 3
Hydroxychloroquine	1	13.5	3.8	5.2	7.5	−0.5	−3.1	−4.4	−2.7
	2	4.4	7.7	2.4	4.8	3.6	−13.0	−14.8	−8.1
	80	1.9	4.1	3.7	3.2	14.2	6.0	0.2	6.8
	400	2.7	4.0	2.4	3.1	−8.3	5.8	4.6	0.7
	800	4.2	2.5	2.6	3.1	13.9	−1.5	−1.4	3.7
Artemisinin	1	13.8	3.5	4.1	7.1	6.1	1.7	1.3	3.1
	2	9.0	4.8	8.0	7.3	−3.8	1.6	−0.2	−0.8
	80	4.6	2.4	3.5	3.5	−10.1	−2.6	−13.4	−8.7
	400	2.8	2.8	4.0	3.2	−8.8	−0.2	0.8	−2.7
	800	3.5	2.4	2.4	2.8	−8.1	−3.4	−4.3	−5.3