Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs

Table 3

Individual differences in pharmacokinetic parameters of hydroxychloroquine and artemisinin in rats.

Parameters	Hydroxychloroquine, precision (RSD, %)			Artemisinin, precision (RSD, %)
				Female			Male
	Low-dose	Mid-dose	High-dose	Low-dose	Mid-dose	High-dose	Low-dose	Mid-dose	High-dose
Cmax	32.7	18.3	30.1	72.6	44.3	84.0	78.6	102.1	72.3
Tmax	41.0	21.4	54.4	95.2	70.8	54.5	95.2	61.3	85.6
t1/2	28.1	17.8	30.3	18.6	23.9	88.6	123.9	66.9	60.8
MRT0−∞	21.6	9.6	23.7	15.4	15.0	52.0	114.1	47.0	75.7
Vd	52.4	13.7	21.5	37.4	59.7	119.0	159.1	50.5	75.0
CL	23.0	11.1	28.4	42.8	45.1	43.6	54.8	72.1	92.6
AUC0−t	20.4	9.6	21.5	41.6	47.0	61.6	88.8	137.2	74.6
AUC0−∞	18.7	10.7	25.0	42.5	46.5	57.0	66.9	137.1	67.4