Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs

Table 4

Pharmacokinetic parameters of hydroxychloroquine in dogs after oral administration.

Parameters	Low-dose	Mid-dose	High-dose
Cmax (ng/mL)	269.0 ± 164.4	534.2 ± 241.1	1183.8 ± 352.5
Tmax (h)	1.4 ± 1.1	1.8 ± 0.8	2.9 ± 2.7
t1/2 (h)	25.4 ± 3.5	22.2 ± 6.8	21.4 ± 8.0
MRT0−∞ (h)	33.9 ± 4.8	29.5 ± 9.4	26.7 ± 8.0
Vd (mL/kg)	123.8 ± 19.1	109.9 ± 22.7	108.8 ± 45.7
CL (mL/h/kg)	3.4 ± 0.8	3.5 ± 0.6	3.5 ± 0.5
AUC0−t (h × ng/mL)	3970.4 ± 821.4	7681.9 ± 1147.5	15644.0 ± 2610.2
AUC0−∞ (h × ng/mL)	4492.5 ± 1042.7	8593.0 ± 1520.3	17078.6 ± 2875.9

significant difference from low-dose and significant difference from mid-dose.