Research Article
Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs
Table 6
Toxicokinetic parameters of hydroxychloroquine in dogs after oral administration.
| | Parameters | Low-dose | Mid-dose | High-dose | | Day 1 | Day 14 | Day 1 | Day 14 | Day 1 | Day 14 |
| | Cmax (ng/mL) | 222.4 ± 68.7 | 293.7 ± 97.4 | 454.0 ± 122.2 | 440.4 ± 161.5 | 597.0 ± 335.0 | 490.6 ± 118.4 | | AUC0−t (h × ng/mL) | 2129.9 ± 586.0 | 3272.5 ± 1258.4 | 3988.5 ± 783.0 | 5208.6 ± 1667.8 | 5722.4 ± 1554.0 | 7118.6 ± 1294.9 | | Accumulation coefficient of Cmax | 1.5 | 1.0 | 1.1 | | Accumulation coefficient of AUC | 1.5 | 1.3 | 1.4 |
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significant difference from day 1. |
