Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway

Figure 1

ZSD attenuated MSU-induced GA in rats. (a) Thickness of the right paw in each group was measured for 0, 24, 48, and 72 h after MSU injection, respectively. (b) After the injection of MSU for 72 h, the swelling of the right paw in each group was observed and photographed. Then, rats were anesthetized again and sacrificed. (c) The pathological changes in the ankle joint were detected by H&E staining. The scale bar = 200 μm. ((d)–(f)) Histopathological changes in the joint space, inflammatory cell infiltration, and cartilage erosion were scored. Results were expressed as means ± SD (n = 6). ^###P < 0.001 compared with the control group; ^∗∗P < 0.01 and ^∗∗∗P < 0.001 compared with the MSU group. ZSD: Zisheng Shenqi Decoction; MSU: monosodium urate; GA: gouty arthritis; H&E: hematoxylin and eosin.

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