QiangGuYin Modulates the OPG/RANKL/RANK Pathway by Increasing Secretin Levels during Treatment of Primary Type I Osteoporosis

Figure 1

Representative 3D reconstruction images of bone microarchitecture of the coronal plane of bone of micro-CT (a) and distal femur micro-CT scans (b). Effect of QiangGuYin (QGY) treatment on bone parameters, including (c) bone mineral density (BMD), (d) bone volume/tissue volume (BV/TV), (e) trabecular number (Tb. N), (f) trabecular thickness (Tb. Th), and (g) trabecular separation (Tb. Sp) in the distal femurs of mice. Data are expressed as the mean ± SD (n = 6). vs. the Con group; vs. the Sec-kno group. Groups are as follows: control group (Con), secretin overexpression group (Sec-over), secretin overexpression control group (Sec-over-Con), secretin overexpression + QGY group (Sec-over + Q), secretin knockdown group (Sec-kno), secretin knockdown control group (Sec-kno-Con), and secretin knockdown + QGY group (Sec-kno + Q).

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