Ethyl Acetate Fraction from Leandra dasytricha (A. Gray) Cong. Leaves Promotes Vasodilatation and Reduces Blood Pressure in Normotensive and Hypertensive Rats

Table 2

Effects of EAF (0.3, 1, and 3 mg/kg) treatment on the blood pressure of normotensive rats (NTRs) and hypertensive rats (SHRs).

Groups	Vehicle	Acetylcholine 10 nmol/kg	EAF 0.3 mg/kg	EAF 1 mg/kg	EAF 3 mg/kg
NTR
MAP (mm Hg)	—	−12.82 ± 3.07	−4.07 ± 1.99	−11.78 ± 3.55	−24.20 ± 2.45
SAP (mm Hg)	—	−12.44 ± 4.03	−3.47 ± 2.21	−12.20 ± 3.56	−24.22 ± 2.30
DAP (mm Hg)	—	−13.71 ± 2.03	−2.08 ± 1.49	−14.08 ± 3.94	−25.36 ± 2.77
SHR
MAP (mm Hg)	—	-20.75 ± 6.86	−2.92 ± 1.68	−10.71 ± 2.32	−21.17 ± 2.46
SAP (mm Hg)	—	−20.92 ± 5.45	−4.09 ± 1.93	−10.70 ± 2.67	−21.37 ± 3.29
DAP (mm Hg)	—	−21.76 ± 6.69	−4.46 ± 1.33	−11.19 ± 1.75	−21.35 ± 1.93

The results show the mean ± S.E.M. of 6 animals in each group. Statistical analyses were performed by means of a one-way analysis of variance followed by Bonferroni's multiple comparison test. when compared to a vehicle, and when compared to EAF 0.3 mg/kg or EAF 1 mg/kg. MAP, mean arterial pressure; SAP, systolic arterial pressure; and DAP, diastolic arterial pressure.